SR 49059
Names
[ CAS No. ]:
150375-75-0
[ Name ]:
SR 49059
[Synonym ]:
reclovaptan
cis-Ned 19
INDOL-2-YLCARBONYL)-L-PROLINAMIDE
Relcovaptan
SR 49059
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Ki: 1.4±0.3 nM (vasopressin V1a)[1].
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.499g/cm3
[ Boiling Point ]:
868ºC at 760mmHg
[ Molecular Formula ]:
C28H27Cl2N3O7S
[ Molecular Weight ]:
620.50
[ Flash Point ]:
478.8ºC
[ Exact Mass ]:
619.09500
[ PSA ]:
147.85000
[ LogP ]:
5.08430
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.664
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
Neuropeptides 51 , 63-73, (2015)
The aim of this study is to investigate local cardiac and circulating AVP secretion during heart failure and to determine whether AVP mediates ventricular remodeling.We assessed cardiac function and A...
Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats.Diabetologia 58(5) , 1081-90, (2015)
High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed t...
Vasopressin-2 receptor antagonist attenuates the ability of the lungs to clear edema in an experimental model.Am. J. Respir. Cell. Mol. Biol. 47(5) , 583-8, (2012)
In the last two decades, the role of the alveolar active sodium transport was extensively studied and was found to play a crucial role in regulating alveolar fluid clearance (AFC), and thus in keeping...