TMPH hydrochloride

Names

[ Name ]:
TMPH hydrochloride

Biological Activity

[Description]:

nAChR-IN-1 (hydrochloride) is a tetramethylpiperidine heptanoate, a selective nicotinic acetylcholine receptor (nAChR) inhibitor that inhibits nAChRs lacking α5, α6, or β3 subunits. nAChR-IN-1 has the effect of preventing nerve disorder, can be used for nicotinic acetylcholine receptor dysfunction or neurological disorders research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. Papke RL, et, al. Compositions et methodes d'inhibition selective des recepteurs nicotiniques de l'acetylcholine. WO2005032479A2

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₃₂ClNO₂

[ Molecular Weight ]:
305.88

[ Exact Mass ]:
305.21200

[ PSA ]:
38.33000

[ LogP ]:
4.94000

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

Levamisole-induced reduction in seizure threshold: a possible role of nicotinic acetylcholine receptor-mediated pathway.

Naunyn Schmiedebergs Arch. Pharmacol. 382(3) , 279-85, (2010)

Levamisole produces seizures in man and is also known to activate the neuronal nicotinic acetylcholine receptors, which are further known to elicit seizure activity. Therefore, the present study has b...