OAC1

Names

[ Name ]:
OAC1

[Synonym ]:
N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide
Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

Biological Activity

[Description]:

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.IC50 value: Target: Oct4 activatorin vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Oct3/4

Research Areas >> Others

[References]

[1]. Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

[Related Small Molecules]

OAC-2 | O4I1 | O4I2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
386.6±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₁N₃O

[ Molecular Weight ]:
237.257

[ Flash Point ]:
187.6±22.3 °C

[ Exact Mass ]:
237.090210

[ PSA ]:
57.78000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.755

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport