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Astressin 2B

Names

[ CAS No. ]:
681260-70-8

[ Name ]:
Astressin 2B

[Synonym ]:
Astressin 2B

Biological Activity

[Description]:

Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR
Research Areas >> Others

[References]

[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.  

[2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.  

[3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.  

Chemical & Physical Properties

[ Molecular Formula ]:
C183H307N49O53

[ Molecular Weight ]:
4041.69000

[ Exact Mass ]:
4039.28000

[ PSA ]:
1686.63000

[ LogP ]:
10.19370

Safety Information

[ Safety Phrases ]:
22-24/25

Related Compounds