Amodiaquin dihydrochloride dihydrate

Names

[ Name ]:
Amodiaquin dihydrochloride dihydrate

[Synonym ]:
UNII:K6PW2S574L
Amodiaquine hydrochloride USP24
Amodiaquin dihydrochloride dihydrate
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE
MFCD00078857
Amodiaquin hydrochloride dihydrate
AMODIAQUIN HYDROCHLORIDE
AMODIAQUINE 2HCL DIHYDRATE
EINECS 200-706-0
Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride, hydrate (1:2:2)
AMODIAQUIN DIHYDROCHLORIDE
AMODIAQUINE HCL
4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE

Biological Activity

[Description]:

Amodiaquine dihydrochloride dihydrate is a histamine N-methyltransferase inhibitor, used as an antimalarial and anti-inflammatory agent.Target: histamine N-methyltransferaseAmodiaquine has been shown to be more effective than chloroquine in treating chloroquine-resistant Plasmodium falciparum malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine is generally well tolerated.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

GSK126 | Tazemetostat (EPZ-6438) | UNC 0642 | GSK343 | Pinometostat (EPZ5676) | 3-Deazaneplanocin A (hydrochloride) | Pemrametostat (GSK3326595) | UNC1999 | BIX-01294 | EPZ031686 | AZ505 (ditrifluoroacetate) | MS023 | EPZ 004777 | EPZ015666 | EPZ015866(GSK591)

Chemical & Physical Properties

[ Boiling Point ]:
535.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂ClN₃O_.2H₂O_.2HCl

[ Molecular Weight ]:
464.81

[ Flash Point ]:
277.6ºC

[ PSA ]:
48.39000

[ LogP ]:
6.85620

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Inhibition of influenza virus replication by targeting broad host cell pathways.

PLoS ONE 9(10) , e110631, (2014)

Antivirals that are currently used to treat influenza virus infections target components of the virus which can mutate rapidly. Consequently, there has been an increase in the number of resistant stra...