MRS-2365

Names

[ Name ]:
MRS-2365

[Synonym ]:
MRS-2365

Biological Activity

[Description]:

MRS2365 is a potent and selective P2Y1 receptor agonist with an EC50 of 0.4 nM. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

[In Vitro]

Selective activation of the P2Y1 receptor also is suggested from functional studies of human platelets as MRS2365 potently induced shape change without causing the sustained aggregation that is a hallmark of simultaneous activation of the P2Y1 and P2Y12 receptors by ADP or by previously studied ADP analogues[2].

[References]

[1]. Mariya Chhatriwala, et al. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43.

[2]. D M Bourdon, et al. (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. J Thromb Haemost. 2006 Apr;4(4):861-8.

Chemical & Physical Properties

[ Density]:
2.37±0.1 g/cm3(Predicted)

[ Boiling Point ]:
875.5±75.0 °C(Predicted)

[ Molecular Formula ]:
C₁₃H₁₆N₅Na₃O₉P₂S

[ Molecular Weight ]:
549.27600

[ Exact Mass ]:
548.98400

[ PSA ]:
276.78000

[ LogP ]:
1.53530

[ Storage condition ]:
2-8°C

MRS-2365

Names

Biological Activity

Chemical & Physical Properties

Related Compounds