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R 568 hydrochloride

Names

[ CAS No. ]:
177172-49-5

[ Name ]:
R 568 hydrochloride

[Synonym ]:
Norcalcin
R-568
Tecalcet hydrochloride
KRN-568
NPS R-568
Tecalcet HCl

Biological Activity

[Description]:

Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> CaSR

[References]

[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997).

[2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996).

[3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998).

Chemical & Physical Properties

[ Boiling Point ]:
416.3ºC at 760 mmHg

[ Molecular Formula ]:
C18H23Cl2NO

[ Molecular Weight ]:
340.28700

[ Flash Point ]:
205.6ºC

[ Exact Mass ]:
339.11600

[ PSA ]:
21.26000

[ LogP ]:
5.82490

[ Vapour Pressure ]:
3.86E-07mmHg at 25°C

Related Compounds