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(+)-Igmesine hydrochloride

Names

[ CAS No. ]:
130152-35-1

[ Name ]:
(+)-Igmesine hydrochloride

[Synonym ]:
Cinnamyl-1-phenyl-1-N-methyl-N-cyclopropylene
JO-1784
Igmesine hydrochloride
Sipatrigine
CI-1019

Biological Activity

[Description]:

(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[References]

[1]. O'Neill M, et al. The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur J Pharmacol. 1995 Sep 5;283(1-3):217-25.  

Chemical & Physical Properties

[ Density]:
1.027g/cm3

[ Boiling Point ]:
445.1ºC at 760mmHg

[ Molecular Formula ]:
C23H30ClN

[ Molecular Weight ]:
355.94

[ Flash Point ]:
196.9ºC

[ Exact Mass ]:
355.20700

[ PSA ]:
3.24000

[ LogP ]:
6.53920

Related Compounds