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Apelin 17

Names

[ CAS No. ]:
217082-57-0

[ Name ]:
Apelin 17

[Synonym ]:
h-lys-phe-arg-arg-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe-oh trifluoroacetate

Biological Activity

[Description]:

Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1

HIV-2


[References]

[1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

[2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

[3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C96H156N34O20S

[ Molecular Weight ]:
2138.55000

[ Exact Mass ]:
2137.20000

[ PSA ]:
919.49000

[ LogP ]:
4.58470

Related Compounds