8-CPT-2Me-cAMP sodium

Names

[ Name ]:
8-CPT-2Me-cAMP sodium

[Synonym ]:
8-pCPT-2gamma-O-Me-cAMP
8-pCPT-2 inverted exclamation marka-O-Me-cAMP
8-pCPT-2'-O-Me-cAMP

Biological Activity

[Description]:

8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM)[1]. 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002 Nov;4(11):901-6.

[2]. Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem. 2003 Mar 7;278(

Chemical & Physical Properties

[ Melting Point ]:
235.5-237.5 â„ƒ(lit.)

[ Molecular Formula ]:
C₁₇H₁₆ClN₅NaO₆PS

[ Molecular Weight ]:
525.83600

[ Exact Mass ]:
525.02500

[ PSA ]:
191.01000

[ LogP ]:
3.59640

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
22-24/25