(2R,4R)-APDC

Names

[ Name ]:
(2R,4R)-APDC

[Synonym ]:
4-amino-2,4-pyrrolidinedicarboxylic acid
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid

Biological Activity

[Description]:

(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vivo]

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2]. Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2] Dosage: 1 nmol/10 μl; 10 nmol/10μl Administration: ICV; daily for 14 days Result: Resulted in decreased BrdU-immunoreactive cells in the DG.

[References]

[1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54.

[2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₀N₂O₄

[ Molecular Weight ]:
174.15500

[ Exact Mass ]:
174.06400

[ PSA ]:
112.65000

(2R,4R)-APDC

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds