Fluorescein
Names
[ CAS No. ]:
2321-07-5
[ Name ]:
Fluorescein
[Synonym ]:
D and C Yellow No. 7
D&C Yellow No. 7
D+C Yellow No. 7
Fluorescein (free acid)
3',6'-Dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
3',6'-Fluorandiol
Fluorecein
Eosin
YELLOW 7
3',6'-Dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
KI201
MFCD00005050
Acid Yellow 73
3',6'-Dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
Fluorescite
EINECS 219-031-8
Uranine Yellow
C.I. Acid Yellow 73
angiofluor
Soluble fluorescein
D & C Yellow no. 7
Fluor-I-Strip
D & C Yellow no. 8
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-
Fluorescein
Ful-Glo
Funduscein
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
620.8±55.0 °C at 760 mmHg
[ Melting Point ]:
320 °C(lit.)
[ Molecular Formula ]:
C20H12O5
[ Molecular Weight ]:
332.306
[ Flash Point ]:
232.6±25.0 °C
[ Exact Mass ]:
332.068481
[ PSA ]:
87.74000
[ LogP ]:
2.98
[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C
[ Index of Refraction ]:
1.792
[ Storage condition ]:
−20°C
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LM5075000
- CHEMICAL NAME :
- Fluorescein
- CAS REGISTRY NUMBER :
- 2321-07-5
- BEILSTEIN REFERENCE NO. :
- 0094324
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C20-H12-O5
- MOLECULAR WEIGHT :
- 332.32
- WISWESSER LINE NOTATION :
- T C666 BO EVJ IR BVQ& MQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 15 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33350 No. of Facilities: 495 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 5188 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33350 No. of Facilities: 2171 (estimated) No. of Industries: 42 No. of Occupations: 55 No. of Employees: 88495 (estimated) No. of Female Employees: 21558 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36;R43
[ Safety Phrases ]:
S22-S24/25-S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LM5075000
[ Packaging Group ]:
I; II; III
[ HS Code ]:
3204200000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Oncotarget 5(16) , 6756-69, (2014)
Glioma stemness has been recognized as the most important reason for glioma relapse and drug resistance. Differentiation of glioma stem cells (GSCs) has been implicated as a novel approach to target r...
Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.PLoS ONE 9(7) , e101824, (2014)
Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon ...
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.Brain Behav. 3(2) , 75-88, (2013)
Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson's disea...