Aristololactam I

Names

[ Name ]:
Aristololactam I

[Synonym ]:
1,3-Benzodioxolo[6,5,4-cd]benz[f]indol-5(6H)-one, 8-methoxy-
Aristololactam
8-Methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one

Biological Activity

[Description]:

Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Inflammation/Immunology

[References]

[1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
463.9±34.0 °C at 760 mmHg

[ Melting Point ]:
319 °C

[ Molecular Formula ]:
C₁₇H₁₁NO₄

[ Molecular Weight ]:
293.273

[ Flash Point ]:
234.4±25.7 °C

[ Exact Mass ]:
293.068817

[ PSA ]:
60.55000

[ LogP ]:
2.97

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.763

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE5375000

CHEMICAL NAME :: Benzo(f)-1,3-benzodioxolo(6,5,4-cd)indol-5(6H)-one, 8-methoxy-

CAS REGISTRY NUMBER :: 13395-02-3

BEILSTEIN REFERENCE NO. :: 0307971

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H11-N-O4

MOLECULAR WEIGHT :: 293.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ug/plate

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 7,59,1986

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%