Ebselen

Names

[ Name ]:
Ebselen

[Synonym ]:
2-Phenyl-1,2-benzoselenazol-3(2H)-one
1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-
Ebselenum
2-phenyl-1,2-benzoselenazol-3-one
Harmokisane
Ebselen
MFCD00210937
Ebseleno
Ebselene

Biological Activity

[Description]:

Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Inflammation/Immunology

[References]

[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.

[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
402.8±28.0 °C at 760 mmHg

[ Melting Point ]:
178-181 °C

[ Molecular Formula ]:
C₁₃H₉NOSe

[ Molecular Weight ]:
274.177

[ Flash Point ]:
197.4±24.0 °C

[ Exact Mass ]:
274.984924

[ PSA ]:
22.00000

[ LogP ]:
2.04770

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4140750

CHEMICAL NAME :: 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

CAS REGISTRY NUMBER :: 60940-34-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H9-N-O-Se

MOLECULAR WEIGHT :: 274.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H331-H373-H410

[ Precautionary Statements ]:
P261-P273-P301 + P310-P311-P501

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/25;R33;R50/53

[ Safety Phrases ]:
S20/21-S28-S45-S60-S61-S28A

[ RIDADR ]:
UN 3283 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
DE4140750

[ HS Code ]:
2927000090

Customs

[ HS Code ]: 2927000090

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiati...

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

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The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its re...

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