Ebselen
Names
[ CAS No. ]:
60940-34-3
[ Name ]:
Ebselen
[Synonym ]:
2-Phenyl-1,2-benzoselenazol-3(2H)-one
Ebselenum
2-phenyl-1,2-benzoselenazol-3-one
Harmokisane
Ebselen
MFCD00210937
Ebseleno
Ebselene
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
402.8±28.0 °C at 760 mmHg
[ Melting Point ]:
178-181 °C
[ Molecular Formula ]:
C13H9NOSe
[ Molecular Weight ]:
274.177
[ Flash Point ]:
197.4±24.0 °C
[ Exact Mass ]:
274.984924
[ PSA ]:
22.00000
[ LogP ]:
2.04770
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE4140750
- CHEMICAL NAME :
- 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-
- CAS REGISTRY NUMBER :
- 60940-34-3
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C13-H9-N-O-Se
- MOLECULAR WEIGHT :
- 274.19
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H331-H373-H410
[ Precautionary Statements ]:
P261-P273-P301 + P310-P311-P501
[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R23/25;R33;R50/53
[ Safety Phrases ]:
S20/21-S28-S45-S60-S61-S28A
[ RIDADR ]:
UN 3283 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
DE4140750
[ HS Code ]:
2927000090
Customs
[ HS Code ]: 2927000090
[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Int. Arch. Allergy Immunol. 159(3) , 278-86, (2012)
Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiati...
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.J. Exp. Med. 212(4) , 555-68, (2015)
The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its re...
Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.Mol. Cell. Neurosci. 67 , 116-25, (2015)
Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting act...