Dendrotoxin-I

Names

[ CAS No. ]:
107950-33-4

[ Name ]:
Dendrotoxin-I

Biological Activity

[Description]:

Dendrotoxin-I is a potent K+ channels blocker and targets voltage-gated potassium channel subunits KV1.1 and KV1.2. Dendrotoxin-I is a neurotoxin isolated from thevenom of Dendroaspis snakes[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vivo]

Dendrotoxin-I (5 mg/kg; IV) displays a significant tumor growth inhibition effect combined with hyperthermia[3]. Animal Model: Nude mice with MCF-7 cells[3] Dosage: 5 mg/kg Administration: IV Result: Displayed a significanttumor growth inhibition effect combined with hyperthermia. Could not keep on inhibiting the growth of tumor at the later period of treatment.

[References]

[1]. H Rehm, et al. Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4919-23.  

[2]. Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584.  

[3]. Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103(7):2177-2183.  

Chemical & Physical Properties

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
−20°C

Safety Information

[ WGK Germany ]:
3

Related Compounds