Lacidipine-d10

Names

[ CAS No. ]:
1185245-62-8

[ Name ]:
Lacidipine-d10

[Synonym ]:
GX-1048-d10
Lacipil-d10
Lacidipine-d10
Motens-d10
Caldine-d10
Lacirex-d10

Biological Activity

[Description]:

Lacidipine-d10 is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cardiovascular Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9.

[3]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7.

[4]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H23D10NO6

[ Molecular Weight ]:
465.60500

[ Exact Mass ]:
465.29400

[ PSA ]:
90.93000

[ LogP ]:
4.73130

Related Compounds