Thymidine 3',5'-diphosphate tetrasodium

Names

[ CAS No. ]:
118675-87-9

[ Name ]:
Thymidine 3',5'-diphosphate tetrasodium

Biological Activity

[Description]:

Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) tetrasodium is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit). Thymidine 3',5'-diphosphate tetrasodium exhibits anti-tumor efficacy in vivo[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[Target]

Staphylococcal nuclease and tudor domain containing 1, SND1[1]


[In Vitro]

Thymidine 3',5'-diphosphate tetrasodium (200 µM；18 h) 通过抑制葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1) 酶活性显著降低 WT 和 Alb/SND1 (特异性过表达 SND1 转基因小鼠) 肝细胞中 p65 表达水平和 p65 核易位。Thymidine 3',5'-diphosphate tetrasodium 抑制了 WT 和 Alb/SND1 肝细胞的球形形成[1]。

[In Vivo]

Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg 或 1.6 mg/kg；腹腔注射或静脉注射；每周两次持续四周) 显著抑制 WT B6/CBA 小鼠中人肝癌的异种移植[1]。 Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 和 0.32 mg/kg；皮下注射；每周两次持续四周) 抑制成年雄性 NSG 小鼠中肿瘤增殖、炎症反应和肿瘤起源细胞 (TIC) 标志物的表达。Thymidine 3',5'-diphosphate tetrasodium 上调了凋亡和选择性肿瘤抑制基因的表达[1]。

[References]

[1]. Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H12N2Na4O11P2

[ Molecular Weight ]:
490.12

Related Compounds