Physcion-d3

Names

[ CAS No. ]:
1215751-27-1

[ Name ]:
Physcion-d3

[Synonym ]:
6-(Methoxy-d3)chrysophanic Acid
Parietin-d3
6-O-Methylemodin-d3
1,8-Dihydroxy-3-methyl-6-(methoxy-d3)anthraquinone
Emodin 3-(Methyl-d3) Ether
Rheochrysidin-d3
Physcion-d3

Biological Activity

[Description]:

Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  

[2]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.  

[3]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H9D3O5

[ Molecular Weight ]:
287.28200

[ Exact Mass ]:
287.08700

[ PSA ]:
83.83000

[ LogP ]:
2.19020

Related Compounds