3-(Cyclohexylamino)-1-propanesulfonic Acid-d17

Names

[ CAS No. ]:
1219804-15-5

[ Name ]:
3-(Cyclohexylamino)-1-propanesulfonic Acid-d17

[Synonym ]:
3-[(2H11)Cyclohexylamino]-1-(2H6)propanesulfonic acid
1-Propane-1,1,2,2,3,3-d6-sulfonic acid, 3-(cyclohexyl-d11-amino)-
3-[(2H11)Cyclohexylamino](2H6)propane-1-sulfonic acid

Biological Activity

[Description]:

3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Bedard P R, et al. Ion Interaction: The Energetics and Mechanism of The Competitive Behavior Between Two Similarly Charged Molecules. 1. The Effect of Ionic Strength, Acetonitrile and Surfactant Concentration[J]. Journal of Liquid Chromatography, 1985, 8(13):2417-2443.

[3]. Oberley TD, et al. The effect of the dimeric and multimeric forms of fibronectin on the adhesion and growth of primary glomerular cells. Exp Cell Res. 1983 May145(2):265-76.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C9H2D17NO3S

[ Molecular Weight ]:
238.422

[ Exact Mass ]:
238.215271

[ LogP ]:
0.05

[ Index of Refraction ]:
1.515

Related Compounds