Nampt-IN-7

Names

[ CAS No. ]:
1223378-42-4

[ Name ]:
Nampt-IN-7

Biological Activity

[Description]:

Nampt-IN-7 (compound GF8) is a potent NAMPT inhibitor, with an IC50 of 7.31 μM. Nampt-IN-7 also displays cytotoxic activity against human HepG2 hepatocellular carcinoma cell line with an IC50 of 24.28 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[Target]

IC50: 7.31 ± 1.59 μM (NAMPT)[1]


[References]

[1]. Ozgencil F, et al. Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115217.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21N5O3

[ Molecular Weight ]:
379.41

Related Compounds