LSD1-IN-12

Names

[ CAS No. ]:
1228143-76-7

[ Name ]:
LSD1-IN-12

Biological Activity

[Description]:

LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Demethylase
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

[Target]

MAO-A:2.3 μM (Ki)

MAO-B:3.5 μM (Ki)


[References]

[1]. Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H16N2O

[ Molecular Weight ]:
252.31

Related Compounds