Edaravone D5

Names

[ CAS No. ]:
1228765-67-0

[ Name ]:
Edaravone D5

[Synonym ]:
edaravone d5

Biological Activity

[Description]:

Edaravone D5 is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Research Areas >> Neurological Disease

[References]

[1]. Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev, 2006. 12(1): p. 9-20.

[2]. Okamura, K., et al. Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Neurol Res, 2013.

[3]. Garcia CA, et al. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2016 Dec 17. [Epub ahead of print]

[4]. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H5D5N2O

[ Molecular Weight ]:
179.23000

[ Exact Mass ]:
179.11100

[ PSA ]:
32.67000

[ LogP ]:
1.29980

Related Compounds