PropionylproMazine-D6 hydrochloride

Names

[ CAS No. ]:
1262770-67-1

[ Name ]:
PropionylproMazine-D6 hydrochloride

[Synonym ]:
1-[10-(3-{Bis[(2H3)methyl]amino}propyl)-10H-phenothiazin-2-yl]-1-propanone hydrochloride (1:1)
1-Propanone, 1-[10-[3-(dimethyl-d3-amino)propyl]-10H-phenothiazin-2-yl]-, hydrochloride (1:1)

Biological Activity

[Description]:

Propionylpromazine-d6 hydrochloride is the deuterium labeled Propionylpromazine hydrochloride. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Tyers, Mike, et al. Method for treating a brain cancer with ifenprodil. US8058243.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H19D6ClN2OS

[ Molecular Weight ]:
382.980

[ Exact Mass ]:
382.175262

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds