BACE-1 inhibitor 1

Names

[ CAS No. ]:
1262858-14-9

[ Name ]:
BACE-1 inhibitor 1

Biological Activity

[Description]:

BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC50 of 56 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 56 nM (BACE-1)[1]


[References]

[1]. Veenstra SJ, et al. Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2195-2200.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H14BrF3N4O2

[ Molecular Weight ]:
443.22

Related Compounds