Nonanoic acid-d3

Names

[ CAS No. ]:
134646-27-8

[ Name ]:
Nonanoic acid-d3

Biological Activity

[Description]:

Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Wang J, et al. Caprylic acid and nonanoic acid upregulate endogenous host defense peptides to enhance intestinal epithelial immunological barrier function via histone deacetylase inhibition.Int Immunopharmacol. 2018 Dec;65:303-311.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H15D3O2

[ Molecular Weight ]:
161.26

[ Exact Mass ]:
161.15000

[ PSA ]:
37.30000

[ LogP ]:
2.82160

Related Compounds