EGFR-IN-40

Names

[ CAS No. ]:
1466445-39-5

[ Name ]:
EGFR-IN-40

Biological Activity

[Description]:

EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[Target]

EGFR:5.3 nM (IC50)

BTK:1.2 nM (IC50)

ITK:46.1 nM (IC50)

[References]

[1]. Dou Dou, et al. Discovery of Pteridine-7(8 H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2022 Feb 10;65(3):2694-2709.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀N₆O₃

[ Molecular Weight ]:
428.44

Related Compounds