Ac-Leu-Leu-Norleucinol
Names
[ CAS No. ]:
148333-42-0
[ Name ]:
Ac-Leu-Leu-Norleucinol
Biological Activity
[Description]:
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].
[Related Catalog]:
[Target]
Calpain[1]
[In Vivo]
Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1]. Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1] Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.) Administration: Intraperitoneal injection; collected tissue samples 24 hr after Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). Injection alone did not cause pathological changes in the liver.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H37N3O5
[ Molecular Weight ]:
399.52