LY108742

Names

[ CAS No. ]:
150196-69-3

[ Name ]:
LY108742

[Synonym ]:
ERGOLINE-8-CARBOXYLICACID, 1,6-DIMETHYL-, 2-HYDROXY-1-METHYLPROPYL ESTER
(8β)-1,6-dimethylergoline-8-carboxylic acid,(R-(R*,R*))-2-hydroxy-1-methylpropyl ester

Biological Activity

[Description]:

LY108742 is a 5-HT2 receptor antagonist, with IC50 values of 9.3 nM (Rat), 57.2 nM (Pig), 56.8 nM (Monkey)[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. D L Nelson, et al. Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines. J Pharmacol Exp Ther. 1993 Jun;265(3):1272-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H28N2O3

[ Molecular Weight ]:
356.45900

[ Exact Mass ]:
356.21000

[ PSA ]:
54.70000

[ LogP ]:
2.38870

Related Compounds