(2H3)Hydroxylamine (2H)hydrochloride (1:1)

Names

[ Name ]:
(2H3)Hydroxylamine (2H)hydrochloride (1:1)

[Synonym ]:
(H)Hydroxylamine (H)hydrochloride (1:1)
hydroxylamine hydrochloride-d4
Hydroxylamine-d, hydrochloride-d (1:1)

Biological Activity

[Description]:

Hydroxylamine-d3 (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Roh JH, et al. Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12. Biosci Biotechnol Biochem. 1994 Sep;58(9):1652-6.

Chemical & Physical Properties

[ Melting Point ]:
156-158ºC(lit.)

[ Molecular Formula ]:
ClD₄NO

[ Molecular Weight ]:
73.516

[ Exact Mass ]:
73.023247

[ PSA ]:
46.25000

[ LogP ]:
0.83660

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H290-H302-H312-H315-H317-H319-H351-H373-H400

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R5

[ Safety Phrases ]:
22-24-26-37-45-61

[ RIDADR ]:
UN 2923 8/PG 2