RIPK1-IN-13

Names

[ CAS No. ]:
1574547-67-3

[ Name ]:
RIPK1-IN-13

Biological Activity

[Description]:

RIPK1-IN-13 (Compound 8) is a potent inhibitor of RIPK1 with an IC50 value of 1139 nM. RIPK1-IN-13 blocks the activation of the necroptosis pathway via the inhibition of RIPK1. RIPK1-IN-13 has the potential for the research of inflammation diseases[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase
Research Areas >> Inflammation/Immunology

[References]

[1]. Niu A, et al. Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors. Bioorg Med Chem. 2022 Apr 1;59:116686.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20ClN3O3

[ Molecular Weight ]:
397.85

Related Compounds