Thrombin inhibitor 6
Names
[ CAS No. ]:
1628224-94-1
[ Name ]:
Thrombin inhibitor 6
Biological Activity
[Description]:
Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].
[Related Catalog]:
[In Vitro]
Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg;Clint (人) = 17 μL/min/mg)[1].
[In Vivo]
Thrombin inhibitor 6 (compound 73) (9 mg/kg,静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]。 Thrombin inhibitor 6 (compound 73) (5 mg/kg,口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%,AUC 为 713.3 h.ng/mL,Cmax 为 127 ng/mL[1]。 Animal Model: CD-1 mice[1] Dosage: 9 mg/kg Administration: Intravenous injection (i.v.) Result: The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H19ClN4O2S
[ Molecular Weight ]:
390.89