Gallopamil

Names

[ Name ]:
Gallopamil

[Synonym ]:
MFCD00058000
5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile

Biological Activity

[Description]:

Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil acts on the vascular system and the heart and nodal structure[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[Target]

Ca2+

[References]

[1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115.

[2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14.

Chemical & Physical Properties

[ Density]:
1.068g/cm3

[ Boiling Point ]:
605.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₄₀N₂O₅

[ Molecular Weight ]:
521.08900

[ Flash Point ]:
320.2ºC

[ Exact Mass ]:
520.27000

[ PSA ]:
73.18000

[ LogP ]:
5.66408

[ Vapour Pressure ]:
1.25E-14mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Force response to stretches in activated frog muscle fibres at low tension.

Adv. Exp. Med. Biol. 538 , 429-38; discussion 438-9, (2003)

Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells.

Am. J. Physiol. Cell Physiol. 296(4) , C889-99, (2009)

It has been suggested that store-operated Ca(2+) entry (SOC) facilitates catecholamine secretion and synthesis in bovine adrenal medullary (AM) cells. However, there has been no experimental result cl...

Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells.

Eur. J. Pharmacol. 573(1-3) , 39-48, (2007)

Calcium currents (I(Ca)) in inner hair cells (IHCs) are carried by the Ca(v)1.3 subtype of L-type calcium channels. They play an important role in synaptic transmission of sound-evoked mechanical stim...