mGlu4 receptor agonist 1

Names

[ CAS No. ]:
1678501-16-0

[ Name ]:
mGlu4 receptor agonist 1

Biological Activity

[Description]:

mGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC50 of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR4:308 ± 35 nM (EC50)


[References]

[1]. Stankiewicz A, et al. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. J Enzyme Inhib Med Chem. 2022 Dec;37(1):211-225.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H15ClN4O2

[ Molecular Weight ]:
390.82

Related Compounds