FR181157

Names

[ CAS No. ]:
171046-15-4

[ Name ]:
FR181157

[Synonym ]:
Acetic acid,(3-((2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt,(S)
Acetic acid,(3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt

Biological Activity

[Description]:

FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[In Vitro]

FR181157 exhibits high binding affinity for the IP receptor with a Ki of 54 nM and anti-aggregative potency with an IC50 of 60 nM[1].

[References]

[1]. Kouji Hattori , et al. A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4277-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H26NNaO4

[ Molecular Weight ]:
487.52

[ Exact Mass ]:
487.17600

[ PSA ]:
75.39000

[ LogP ]:
5.56350

Related Compounds