DMEA-PNU-159682 dichloroacetate

Names

[ CAS No. ]:
1799421-49-0

[ Name ]:
DMEA-PNU-159682 dichloroacetate

Biological Activity

[Description]:

DMEA-PNU-159682 (molecule D12) dichloroacetate is an ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[References]

[1]. Chen Jingkang, et al. Disubstituted maleic amide class connexon for antibody-drug conjugate and its preparation method and application. CN108101825A.

[2]. John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1

Chemical & Physical Properties

[ Molecular Formula ]:
C41H49Cl4N3O18

[ Molecular Weight ]:
1013.65

Related Compounds