Human enteropeptidase-IN-1
Names
[ CAS No. ]:
1802891-23-1
[ Name ]:
Human enteropeptidase-IN-1
Biological Activity
[Description]:
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research[1].
[Related Catalog]:
[Target]
IC50(initial): 20 nM (enteropeptidase)[1] IC50(app): 1.2 nM (enteropeptidase)[1]
[In Vitro]
Human enteropeptidase-IN-1 (compound 6b) has inhibitory activity against enteropeptidase with IC50(initial)* of 20 nM and IC50(app)** of 1.2 nM[1]. (*IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound. **IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H18N4O7
[ Molecular Weight ]:
426.38