Biotin-PEG3-C3-NH2
Names
Biological Activity
[Description]:
Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].
[Related Catalog]:
[Target]
PEGs
[In Vitro]
PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1]. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PROTAC can significantly attenuate tumor progression in tumor xenografts[1]. Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].
Chemical & Physical Properties
[ Density]:
1.139±0.06 g/cm3(Predicted)
[ Boiling Point ]:
715.3±60.0 °C(Predicted)
[ Molecular Formula ]:
C20H38N4O5S
[ Molecular Weight ]:
446.60