Teicoplanin sodium

Names

[ CAS No. ]:
184539-13-7

[ Name ]:
Teicoplanin sodium

Biological Activity

[Description]:

Teicoplanin sodium (Antibiotic MDL-507 sodium) is a potent lipoglycopeptide antibiotic. Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

MRSA[2]


[In Vitro]

Teicoplanin sodium 显示出抗病毒活性，对 HEK293T 细胞中的 HIV-luc/SARS-CoV-S 病毒、A549 细胞中的 2019-nCoV-Spike-病毒和Vero E6 细胞中的 SARS-CoV-2 病毒的 IC50 值分别为 0.39、1.66、15.7 µM[1]。 Teicoplanin sodium 可抑制人 CEM 细胞培养物中的 HIV-1 病毒，EC50 值为 17 µM[1]。 其机制是通过 Teicoplanin sodium 亲脂部分与酶的相互作用抑制抑制组织蛋白酶 L 活性并阻止 SARS-CoV 从晚期内体释放[1]。 Teicoplanin sodium 表现出抗 MRSA 活性，对 MRSA ATCC 43300 的 MIC 值为 0.5 mg/L[2]。

[In Vivo]

Teicoplanin sodium (10, 30 mg/kg; i.v.) 在小鼠 MRSA 大腿感染模型中表现出剂量依赖性的总细菌密度下降[2]。 Animal Model: 20-30 g, Male CD1 mice (2 * 106 cfu/mL MRSA (43 300) 50 µL; murine thigh infection model)[2] Dosage: 10, 30 mg/kg Administration: I.v.; once every 12 h Result: Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10 mg/kg/day and suppression of resistance with dosages ≥30 mg/kg/day.

[References]

[1]. Vimberg V. Teicoplanin-A New Use for an Old Drug in the COVID-19 Era? Pharmaceuticals (Basel). 2021 Nov 26;14(12):1227.  

[2]. Ramos-Martín V, et al. Pharmacodynamics of teicoplanin against MRSA. J Antimicrob Chemother. 2017 Dec 1;72(12):3382-3389.  

Chemical & Physical Properties

[ Molecular Weight ]:
1564.3-1907.7

Related Compounds