Bromodomain inhibitor-9

Names

[ CAS No. ]:
1870849-34-5

[ Name ]:
Bromodomain inhibitor-9

Biological Activity

[Description]:

Bromodomain inhibitor-9 is a Bromodomains inhibitor that selectively inhibits BRD4-1 (Kd: 12 nM). Bromodomain inhibitor-9 can be used in the research of diseases or conditions associated with systemic or tissue inflammation, lipid metabolism, fibrosis or chronic autoimmune diseases[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4-1:12 nM (Kd)

BRD4-2:5600 nM (Kd)


[In Vitro]

Bromodomain inhibitor-9 (Compound 99, 1 h) inhibits LPS induced cytokines (IL12P40) release in PBMCs, with an IC50 value of 400 nM[1].

[References]

[1]. Gerner Seitzberg, et al. Heterocyclic compounds as inhibitors of bromodomains and their preparation. Patent WO2016016316.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H28N4O5S

[ Molecular Weight ]:
484.57

Related Compounds