Mcl-1 inhibitor 9

Names

[ CAS No. ]:
1883727-31-8

[ Name ]:
Mcl-1 inhibitor 9

Biological Activity

[Description]:

Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC50 value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[In Vitro]

Mcl-1 inhibitor 9 (0-22.2 μM; 16 h) inhibits the growth of human multiple myeloma cells[1]. Cell Viability Assay[1] Cell Line: OPM-2 cells Concentration: 0-22.2 μM Incubation Time: 16 hours Result: Showed IC50 value of 104.69 nM.

[References]

[1]. Sean P. Brown, et al. Tetrahydronaphthalene derivatives that inhibit mcl-1 protein. WO2016033486A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H39ClN2O5S

[ Molecular Weight ]:
599.18

Related Compounds