AChE/BuChE-IN-2

Names

[ CAS No. ]:
1946008-31-6

[ Name ]:
AChE/BuChE-IN-2

Biological Activity

[Description]:

AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)[1]


[In Vivo]

AChE/BuChE-IN-2 (Compound 5f) (20 μmol/kg) significantly ameliorates the cognitive performances of scopolamine-treated ICR mice[1].

[References]

[1]. Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28(1):115190.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18N2O2

[ Molecular Weight ]:
318.37

Related Compounds