ODN 105870

Names

[ CAS No. ]:
1965342-40-8

[ Name ]:
ODN 105870

Biological Activity

[Description]:

ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[In Vitro]

ODN 105870 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1]. In case of Imiquimod-stimulated B cells, ODN 105870 (10 μM) reduces the ATP content to the pretreatment level[1].

[References]

[1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds