BuChE-IN-6

Names

[ CAS No. ]:
2003213-07-6

[ Name ]:
BuChE-IN-6

Biological Activity

[Description]:

BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ42 self-aggregation[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Butyrylcholinesterase:0.46 μM (IC50, eqBuChE)

Butyrylcholinesterase:0.51 μM (IC50, hBuChE)


[References]

[1]. Marques CS, et al. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorg Chem. 2020 May;98:103753.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H26N4O2

[ Molecular Weight ]:
366.46

Related Compounds