ER-27319

Names

[ CAS No. ]:
201010-95-9

[ Name ]:
ER-27319

[Synonym ]:
3,4-Hexanediol,3,4-dimethyl-1,6-diphenyl
3,4-dimethyl-1,6-diphenyl-3,4-hexanediol

Biological Activity

[Description]:

ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk
Research Areas >> Inflammation/Immunology

[Target]

10 μM (Syk) in human and rat mast cells[1]


[References]

[1]. Katsuhiro Moriya, et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23): 12539–12544.

[2]. Yoshitaka Sato, et al. IgG-mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129(4):305-13.  

Chemical & Physical Properties

[ Density]:
1.149g/cm3

[ Boiling Point ]:
475.894ºC at 760 mmHg

[ Molecular Formula ]:
C20H22N2O5

[ Molecular Weight ]:
370.40

[ Flash Point ]:
241.613ºC

[ Exact Mass ]:
396.16900

[ PSA ]:
122.62000

[ LogP ]:
3.53240

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.611

Related Compounds