PG-11047 tetrahydrochloride

Names

[ CAS No. ]:
206991-64-2

[ Name ]:
PG-11047 tetrahydrochloride

Biological Activity

[Description]:

PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77.

[2]. Murray Stewart T, et al. A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. Cancer Chemother Pharmacol. 2021 Jan;87(1):135-144.

Chemical & Physical Properties

[ Density]:
0.888g/cm3

[ Boiling Point ]:
367.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₃₆Cl₄N₄

[ Molecular Weight ]:
402.27

[ Flash Point ]:
178.3ºC

[ Exact Mass ]:
256.26300

[ PSA ]:
53.32000

[ LogP ]:
2.28460