Cyclooctyne-O-amido-PEG2-NHS ester

Names

[ CAS No. ]:
2101206-22-6

[ Name ]:
Cyclooctyne-O-amido-PEG2-NHS ester

Biological Activity

[Description]:

Cyclooctyne-O-amido-PEG2-NHS ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H30N2O8

[ Molecular Weight ]:
438.47

Related Compounds