MAO-B-IN-13

Names

[ CAS No. ]:
2105918-34-9

[ Name ]:
MAO-B-IN-13

Biological Activity

[Description]:

MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor with an IC50 value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

MAO-B:10 nM (IC50)


[In Vitro]

MAO-B-IN-13 (compound 12a) (1 μM, 10 μM and 50 μM; 48 hours) has neuroprotective effect on H2O2-induced PC-12 cell injury[1].

[References]

[1]. Li W, et al. Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease. Bioorg Chem. 2020 Apr;97:103707.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19NO3

[ Molecular Weight ]:
297.35

Related Compounds