MurA-IN-2

Names

[ CAS No. ]:
2164447-18-9

[ Name ]:
MurA-IN-2

Biological Activity

[Description]:

MurA-IN-2 (compound 37), a chloroacetamide fragment containing a primary aliphatic amine, is a potent MurA inhibitor with an IC50 value of 39  μM. MurA-IN-2 has antibacterial activity and inhibits the bacterial cell wall synthesis[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 39 μM (MurA)[1]


[In Vitro]

MurA-IN-2 (compound 37; 128 μg/mL) inhibits bacteria S. aureus ATCC29213 and E. coli ATCC25922 activity[1].

[References]

[1]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752.

[2]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H20ClNO

[ Molecular Weight ]:
229.75

Related Compounds