EphA2 agonist 2

Names

[ CAS No. ]:
2169273-66-7

[ Name ]:
EphA2 agonist 2

Biological Activity

[Description]:

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor

[In Vitro]

EphA2 agonist 2 (Lead compound) shows antiproliferation activity with IC50 values of 2.1 ± 1.05 μM and 5.2 ± 2.56 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

[References]

[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

Chemical & Physical Properties

[ Molecular Formula ]:
C40H56N10O6

[ Molecular Weight ]:
772.94

Related Compounds