IDH1 Inhibitor 3

Names

[ CAS No. ]:
2171081-24-4

[ Name ]:
IDH1 Inhibitor 3

Biological Activity

[Description]:

IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC50 of 45 nM for IDH1R132H[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

[Target]

IC50: 45 nM (IDH1R132H)[1].

[References]

[1]. Qiangang Zheng, et al. Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors. Bioorganic & Medicinal Chemistry Letters 27 (2017) 5262-5266.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₂₅F₄N₅O₃

[ Molecular Weight ]:
591.56

Related Compounds